| Host: | Mouse |
| Applications: | WB/ICC |
| Reactivity: | Chicken/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Nucleoporin p62 (N-Term) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | M436 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500IHCICC 1:50IP |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP62 |
| Gene ID: | 23636 |
| Uniprot ID: | NUP62_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | This antibody detects a 62 kDa* protein corresponding to the apparent molecular mass of nucleoporin p62 on SDS-PAGE immunoblots of human HeLa and rat A7r5 cells. In immunocytochemistry, anti-Nucleoporin p62 specifically stains nuclei and nuclear enve |
| Immunogen: | Clone M436 was generated from a recombinant protein containing amino acid residues in the N-terminal region of human nucleoporin p62. This sequence has high homology to similar regions in rat, mouse, and chicken nucleoporin p62. |
| Function | Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. |
| Protein Name | Nuclear Pore Glycoprotein P6262 Kda NucleoporinNucleoporin Nup62 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmCytoskeletonSpindle PoleNucleus EnvelopeMicrotubule Organizing CenterCentrosomeCentral Region Of The Nuclear PoreWithin The TransporterDuring Mitotic Cell DivisionIt Associates With The Poles Of The Mitotic Spindle |
| Alternative Antibody Names | Anti-Nuclear Pore Glycoprotein P62 antibodyAnti-62 Kda Nucleoporin antibodyAnti-Nucleoporin Nup62 antibodyAnti-NUP62 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
