| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP214 |
| Gene ID: | 8021 |
| Uniprot ID: | NU214_HUMAN |
| Immunogen Region: | 750-1030 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-1030 of human NUP214 (NP_005076.3). |
| Immunogen Sequence: | FLLEIKETTESLHGDISSLK TTLLEGFAGVEEAREQNERN RDSGYLHLLYKRPLDPKSEA QLQEIRRLHQYVKFAVQDVN DVLDLEWDQHLEQKKKQRHL LVPERETLFNTLANNREIIN QQRKRLNHLVDSLQQLRLYK QTSLWSLSSAVPSQSSIHSF DSDLESLCNALLKTTIESHT KSLPKVPAKLSPMKQAQLRN FLAKRKTPPVRSTAPASLSR SAFLSQRYYEDLDEVSSTS |
| Tissue Specificity | Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development. |
| Post Translational Modifications | Probably glycosylated as it reacts with wheat germ agglutinin (WGA). |
| Function | Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup214214 Kda NucleoporinNucleoporin Nup214Protein Can |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-450520Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexCytoplasmic Side Of The Nuclear Pore Complex |
| Alternative Antibody Names | Anti-Nuclear Pore Complex Protein Nup214 antibodyAnti-214 Kda Nucleoporin antibodyAnti-Nucleoporin Nup214 antibodyAnti-Protein Can antibodyAnti-NUP214 antibodyAnti-CAIN antibodyAnti-CAN antibodyAnti-KIAA0023 antibody |
Information sourced from Uniprot.org
