Anti-NUCB2 antibody (321-420) (STJ114515)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NUCB2 (321-420) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUCB2 |
| Gene ID | 4925 |
| Uniprot ID | NUCB2_HUMAN |
| Immunogen Region | 321-420 |
| Immunogen Sequence | ATEKKEFLEPDSWETLDQQQ FFTEEELKEYENIIALQENE LKKKADELQKQKEELQRQHD QLEAQKLEYHQVIQQMEQKK LQQGIPPSGPAGELKFEPHI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 321-420 of human NUCB2 (NP_005004.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in spleen, testis and normal stomach. |
| Function | Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion. |
| Protein Name | Nucleobindin-2Dna-Binding Protein NefaEpididymis Secretory Protein Li 109Gastric Cancer Antigen Zg4Prepronesfatin Cleaved Into - Nesfatin-1 |
| Database Links | |
| Cellular Localisation | Golgi ApparatusMembranePeripheral Membrane ProteinCytoplasmSecretedEndoplasmic ReticulumNucleus EnvelopeGolgi Retention Is Mediated By Its N-Terminal RegionNesfatin-1: Secreted |
| Alternative Antibody Names | Anti-Nucleobindin-2 antibodyAnti-Dna-Binding Protein Nefa antibodyAnti-Epididymis Secretory Protein Li 109 antibodyAnti-Gastric Cancer Antigen Zg4 antibodyAnti-Prepronesfatin Cleaved Into - Nesfatin-1 antibodyAnti-NUCB2 antibodyAnti-NEFA antibody |
Information sourced from Uniprot.org