| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUB1 |
| Gene ID: | 51667 |
| Uniprot ID: | NUB1_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFT140 (NP_001350458.1). |
| Immunogen Sequence: | MAQKKYLQAKLTQFLREDRI QLWKPPYTDENKKVGLALKD LAKQYSDRLECCENEVEKVI EEIRCKAIERGTGNDNYRTT GIATIEVFLPPRLKKDRKNL |
| Tissue Specificity | Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2. |
| Function | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. |
| Protein Name | Nedd8 Ultimate Buster 1Negative Regulator Of Ubiquitin-Like Proteins 1Renal Carcinoma Antigen Ny-Ren-18 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusPredominantly Nuclear |
| Alternative Antibody Names | Anti-Nedd8 Ultimate Buster 1 antibodyAnti-Negative Regulator Of Ubiquitin-Like Proteins 1 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-18 antibodyAnti-NUB1 antibodyAnti-NYREN18 antibody |
Information sourced from Uniprot.org