Anti-NTSR1 antibody [SAA1622] (STJA0020050)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Neurotensin Receptor Type 1 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1622 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | NTSR1 |
| Gene ID | 4923 |
| Uniprot ID | NTR1_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Palmitoylated.this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. |
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. |
| Protein Name | Neurotensin Receptor Type 1Nt-R-1Ntr1High-Affinity Levocabastine-Insensitive Neurotensin ReceptorNtrh |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftPalmitoylation Is Required For Localization At Cav1-Enriched Membrane Rafts |
| Alternative Antibody Names | Anti-Neurotensin Receptor Type 1 antibodyAnti-Nt-R-1 antibodyAnti-Ntr1 antibodyAnti-High-Affinity Levocabastine-Insensitive Neurotensin Receptor antibodyAnti-Ntrh antibodyAnti-NTSR1 antibodyAnti-NTRR antibody |
Information sourced from Uniprot.org