Anti-NTSR1 antibody (181-230) (STJ94568)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NTR1. AA range:181-230
General Information
| Short Description | Rabbit polyclonal anti-Neurotensin receptor type 1 (181-230) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NTSR1 |
| Gene ID | 4923 |
| Uniprot ID | NTR1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NTR1. AA range:181-230 |
| Immunogen Region | 181-230 |
| Specificity | NTR1 Polyclonal Antibody detects endogenous levels of NTR1 protein. |
Additional Info
| Tissue Specificity | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. |
| Post Translational Modifications | N-glycosylated. Palmitoylated.this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. |
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. |
| Protein Name | Neurotensin Receptor Type 1Nt-R-1Ntr1High-Affinity Levocabastine-Insensitive Neurotensin ReceptorNtrh |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftPalmitoylation Is Required For Localization At Cav1-Enriched Membrane Rafts |
| Alternative Antibody Names | Anti-Neurotensin Receptor Type 1 antibodyAnti-Nt-R-1 antibodyAnti-Ntr1 antibodyAnti-High-Affinity Levocabastine-Insensitive Neurotensin Receptor antibodyAnti-Ntrh antibodyAnti-NTSR1 antibodyAnti-NTRR antibody |
Information sourced from Uniprot.org