| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NTRK3 |
| Gene ID: | 4916 |
| Uniprot ID: | NTRK3_HUMAN |
| Immunogen Region: | 40-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1). |
| Immunogen Sequence: | KTEINCRRPDDGNLFPLLEG QDSGNSNGNASINITDISRN ITSIHIENWRSLHTLNAVDM ELYTGLQKLTIKNSGLRSIQ PRAFAKNPHLRYINLSSNRL TTLSWQLFQTLSLRELQLEQ NFFNCSCDIRWMQLWQEQGE AKLNSQNLYCINADGSQLPL FRMNISQCDLPEISVSHVNL TVREGDNAVITCNGSGSPLP DVDWIVTGLQSINTHQTNLN WTNVHAINLTLVNVTSEDN |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor Receptor Gp145-Trkc Trk-C Neurotrophic Tyrosine Kinase Receptor Type 3 Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-388844 Reactome: R-HSA-6811558 Reactome: R-HSA-9034013 Reactome: R-HSA-9034015 Reactome: R-HSA-9034793 Reactome: R-HSA-9034864 Reactome: R-HSA-9603381 Reactome: R-HSA-9603505 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nt-3 Growth Factor Receptor antibody Anti-Gp145-Trkc antibody Anti-Trk-C antibody Anti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibody Anti-Trkc Tyrosine Kinase antibody Anti-NTRK3 antibody Anti-TRKC antibody |
Information sourced from Uniprot.org