Anti-NTN1 antibody (250-300) {Biotin} (STJ501985)

SKU:
STJ501985-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NTN1 (250-300) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.62-0.68 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NTN1
Gene ID: 9423
Uniprot ID: NET1_HUMAN
Immunogen Region: 250-300
Immunogen: Synthetic peptide taken within amino acid region 250-300 on human Netrin-1 protein.
Tissue Specificity Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Protein Name Netrin-1
Epididymis Tissue Protein Li 131p
Database Links Reactome: R-HSA-373752
Reactome: R-HSA-376172
Reactome: R-HSA-418885
Reactome: R-HSA-418886
Reactome: R-HSA-418890
Reactome: R-HSA-428542
Cellular Localisation Secreted
Cytoplasm
Mainly Secreted
Alternative Antibody Names Anti-Netrin-1 antibody
Anti-Epididymis Tissue Protein Li 131p antibody
Anti-NTN1 antibody
Anti-NTN1L antibody

Information sourced from Uniprot.org

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