Anti-NTHL1 antibody (STJ190803)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Endonuclease III-like protein 1 lyase for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NTHL1 |
| Gene ID | 4913 |
| Uniprot ID | NTH_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | NTHL1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Protein Name | Endonuclease Iii-Like Protein 1Hnth1Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site LyaseDna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110357Reactome: R-HSA-9630221Reactome: R-HSA-9630222 |
| Cellular Localisation | NucleusMitochondrion |
| Alternative Antibody Names | Anti-Endonuclease Iii-Like Protein 1 antibodyAnti-Hnth1 antibodyAnti-Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase antibodyAnti-Dna Glycosylase/Ap Lyase antibodyAnti-NTHL1 antibodyAnti-NTH1 antibodyAnti-OCTS3 antibody |
Information sourced from Uniprot.org