Anti-NTHL1 antibody (190-290) {FITC} (STJ501983)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenC-epitope synthetic peptide taken within amino acid region 190-290 on human NTHL1 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-NTHL1 (190-290) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.64-0.72 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | NTHL1 |
| Gene ID | 4913 |
| Uniprot ID | NTH_HUMAN |
| Immunogen | C-epitope synthetic peptide taken within amino acid region 190-290 on human NTHL1 protein. |
| Immunogen Region | 190-290 |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. |
| Post Translational Modifications | Ubiquitinated by TRIM26.leading to proteasomal degradation. |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. |
| Protein Name | Endonuclease Iii-Like Protein 1Hnth1Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site LyaseDna Glycosylase/Ap Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110357Reactome: R-HSA-9630221Reactome: R-HSA-9630222 |
| Cellular Localisation | NucleusMitochondrion |
| Alternative Antibody Names | Anti-Endonuclease Iii-Like Protein 1 antibodyAnti-Hnth1 antibodyAnti-Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase antibodyAnti-Dna Glycosylase/Ap Lyase antibodyAnti-NTHL1 antibodyAnti-NTH1 antibodyAnti-OCTS3 antibody |
Information sourced from Uniprot.org