Host: | Mouse |
Applications: | IP/WB/IHC-P |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-NTAL is suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry research applications. |
Clonality: | Monoclonal |
Clone ID: | NAP-03 |
Conjugation: | Unconjugated |
Isotype: | IgG2a |
Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
Concentration: | 1 mg/mL |
Storage Instruction: | Store at 2-8°C upon receipt. |
Gene Symbol: | LAT2 |
Gene ID: | 7462 |
Uniprot ID: | NTAL_HUMAN |
Immunogen: | Peptide corresponding to aa 196-212 of human NTAL coupled to KLH. |
Tissue Specificity | Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). |
Post Translational Modifications | Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells.which induces the recruitment of GRB2. May be polyubiquitinated. |
Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
Protein Name | Linker For Activation Of T-Cells Family Member 2 Linker For Activation Of B-Cells Membrane-Associated Adapter Molecule Non-T-Cell Activation Linker Williams-Beuren Syndrome Chromosomal Region 15 Protein Williams-Beuren Syndrome Chromosomal Region 5 Protein |
Database Links | Reactome: R-HSA-2730905 |
Cellular Localisation | Cell Membrane Single-Pass Type Iii Membrane Protein Present In Lipid Rafts |
Alternative Antibody Names | Anti-Linker For Activation Of T-Cells Family Member 2 antibody Anti-Linker For Activation Of B-Cells antibody Anti-Membrane-Associated Adapter Molecule antibody Anti-Non-T-Cell Activation Linker antibody Anti-Williams-Beuren Syndrome Chromosomal Region 15 Protein antibody Anti-Williams-Beuren Syndrome Chromosomal Region 5 Protein antibody Anti-LAT2 antibody Anti-LAB antibody Anti-NTAL antibody Anti-WBS15 antibody Anti-WBSCR15 antibody Anti-WBSCR5 antibody Anti-HSPC046 antibody |
Information sourced from Uniprot.org