![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148940/346564/STJ16100222_1__94501.1681998627.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148940/346565/STJ16100222_2__60103.1681998628.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148940/346564/STJ16100222_1__94501.1681998627.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
| Host: | Mouse |
| Applications: | FC/ICC/IHC-F/IHC-P/WB |
| Reactivity: | Human/Rat/Swine |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-NSP-C is suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RNL-4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS with 0.09% sodium azide |
| Concentration: | 1 mg/mL |
| Dilution Range: | FC 1:50-1:100 ICC IHC-F 1:100 IHC-p 1:100 WB 1:100-1:500 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Immunogen: | synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C |
| Background | In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-4 reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies. |
Information sourced from Uniprot.org