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![Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148938/346561/STJ16100220_2__67776.1681998624.png?c=1 "Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)")
![Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148938/346560/STJ16100220_1__76236.1681998623.png?c=1 "Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)")
Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
Immunogensmall cell lung cancer cell line NCI-H82
General Information
| Short Description | Mouse monoclonal anti-NSP-A and NSP-B for use in FC, ICC, IHC-F, IHC-P and WB in Human, Monkey and Rabbit samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/ICC/IHC-F/IHC-P/WB |
| Host | Mouse |
| Reactivity | Human/Monkey/Rabbit |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RNL-2 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Dilution Range | FC 1:25-1:100ICCIHC-F 1:50IHC-p 1:50WB 1:100-1:1000 |
| Formulation | PBS with 0.09% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | small cell lung cancer cell line NCI-H82 |
Additional Info
| Background | In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-2 recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A) , which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, RNL-2 reacts with brain Purkinje cells, pancreatic islet cells, cells in the pituitary gland and some (peripheral) nerve fibers. In addition, a few epithelia show positive staining. |
Information sourced from Uniprot.org