Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)

Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)

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STJ16100220-100
€670.20
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Short Description :Mouse monoclonal anti-NSP-A and NSP-B for use in FC, ICC, IHC-F, IHC-P and WB in Human, Monkey and Rabbit samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/ICC/IHC-F/IHC-P/WB
Host:Mouse
Reactivity:Human/Monkey/Rabbit
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :RNL-2
Isotype:IgG1
Conjugation:Unconjugated
Concentration:1 mg/mL
Dilution Range:FC 1:25-1:100
ICC
IHC-F 1:50
IHC-p 1:50
WB 1:100-1:1000
Formulation:PBS with 0.09% sodium azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Immunogen:small cell lung cancer cell line NCI-H82
Background In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-2 recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A) , which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, RNL-2 reacts with brain Purkinje cells, pancreatic islet cells, cells in the pituitary gland and some (peripheral) nerve fibers. In addition, a few epithelia show positive staining.

Information sourced from Uniprot.org

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