Anti-NSP-A and NSP-B antibody [RNL-2] (STJ16100220)

SKU:

STJ16100220-100

£489.50

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	FC/ICC/IHC-F/IHC-P/WB
Reactivity:	Human/Monkey/Rabbit
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-NSP-A and NSP-B is suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry and Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	RNL-2
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS with 0.09% sodium azide
Concentration:	1 mg/mL
Dilution Range:	FC 1:25-1:100 ICC IHC-F 1:50 IHC-p 1:50 WB 1:100-1:1000
Storage Instruction:	Store at 2-8°C upon receipt.

Immunogen:

small cell lung cancer cell line NCI-H82

Background

In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-2 recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A) , which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, RNL-2 reacts with brain Purkinje cells, pancreatic islet cells, cells in the pituitary gland and some (peripheral) nerve fibers. In addition, a few epithelia show positive staining.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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