Anti-NRXN1 antibody (502-551) (STJ94421)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551
General Information
| Short Description | Rabbit polyclonal anti-Neurexin-1 (502-551) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRXN1 |
| Gene ID | 9378 |
| Uniprot ID | NRX1A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551 |
| Immunogen Region | 502-551 |
| Specificity | Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein. |
Additional Info
| Tissue Specificity | Brain. |
| Post Translational Modifications | O-glycosylated.contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins and LRRTM2. |
| Function | Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. |
| Protein Name | Neurexin-1Neurexin I-AlphaNeurexin-1-Alpha |
| Database Links | Reactome: R-HSA-6794361Reactome: R-HSA-3000171 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Neurexin-1 antibodyAnti-Neurexin I-Alpha antibodyAnti-Neurexin-1-Alpha antibodyAnti-NRXN1 antibodyAnti-KIAA0578 antibody |
Information sourced from Uniprot.org