• Western blot analysis of NRL Antibody. The lane on the right is blocked with the NRL peptide.
  • Western blot analysis of the lysates from HUVECcells using NRL antibody.
  • Western blot analysis of various cells using Nrl Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-NRL antibody (19-68) (STJ94558)

SKU:
STJ94558

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neural retina-specific leucine zipper protein (19-68) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NRL
Gene ID: 4901
Uniprot ID: NRL_HUMAN
Immunogen Region: 19-68
Specificity: Nrl Polyclonal Antibody detects endogenous levels of Nrl protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68
Tissue Specificity Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
Post Translational Modifications Phosphorylated. Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.
Function Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
Protein Name Neural Retina-Specific Leucine Zipper Protein
Nrl
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Neural Retina-Specific Leucine Zipper Protein antibody
Anti-Nrl antibody
Anti-NRL antibody
Anti-D14S46E antibody

Information sourced from Uniprot.org

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