Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Neural retina-specific leucine zipper protein (19-68) is suitable for use in Western Blot and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
NRL |
Gene ID: |
4901 |
Uniprot ID: |
NRL_HUMAN |
Immunogen Region: |
19-68 |
Specificity: |
Nrl Polyclonal Antibody detects endogenous levels of Nrl protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68 |
Tissue Specificity | Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level). |
Post Translational Modifications | Phosphorylated. Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation. |
Function | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter. |
Protein Name | Neural Retina-Specific Leucine Zipper ProteinNrl |
Cellular Localisation | CytoplasmNucleus |
Alternative Antibody Names | Anti-Neural Retina-Specific Leucine Zipper Protein antibodyAnti-Nrl antibodyAnti-NRL antibodyAnti-D14S46E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance