| Post Translational Modifications | Acetylation regulates its nuclear translocation and corepressive activity. Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. |
| Function | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Protein Name | Nuclear Receptor-Interacting Protein 1Nuclear Factor Rip140Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029558Reactome: R-HSA-9632974Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusLocalized To Discrete Foci And Redistributes To Larger Nuclear Domains Upon Binding To Ligand-Bound Nr3c1 |
| Alternative Antibody Names | Anti-Nuclear Receptor-Interacting Protein 1 antibodyAnti-Nuclear Factor Rip140 antibodyAnti-Receptor-Interacting Protein 140 antibodyAnti-NRIP1 antibody |
Information sourced from Uniprot.org
