| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Pro-neuregulin-2, membrane-bound isoform (361-410 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRG2 |
| Gene ID: | 9542 |
| Uniprot ID: | NRG2_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human NRG2 at the amino acid range 361-410 |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Protein Name | Pro-Neuregulin-2 - Membrane-Bound IsoformPro-Nrg2 Cleaved Into - Neuregulin-2Nrg-2Divergent Of Neuregulin-1Don-1Neural- And Thymus-Derived Activator For Erbb KinasesNtak |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1306955Reactome: R-HSA-1358803Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-2Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-2: Secreted |
| Alternative Antibody Names | Anti-Pro-Neuregulin-2 - Membrane-Bound Isoform antibodyAnti-Pro-Nrg2 Cleaved Into - Neuregulin-2 antibodyAnti-Nrg-2 antibodyAnti-Divergent Of Neuregulin-1 antibodyAnti-Don-1 antibodyAnti-Neural- And Thymus-Derived Activator For Erbb Kinases antibodyAnti-Ntak antibodyAnti-NRG2 antibodyAnti-NTAK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
