| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pro-neuregulin-2, membrane-bound isoform (361-410 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRG2 |
| Gene ID: | 9542 |
| Uniprot ID: | NRG2_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human NRG2 at the amino acid range 361-410 |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Protein Name | Pro-Neuregulin-2 - Membrane-Bound Isoform Pro-Nrg2 Cleaved Into - Neuregulin-2 Nrg-2 Divergent Of Neuregulin-1 Don-1 Neural- And Thymus-Derived Activator For Erbb Kinases Ntak |
| Database Links | Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-1306955 Reactome: R-HSA-1358803 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-2219530 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8863795 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-2 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-2: Secreted |
| Alternative Antibody Names | Anti-Pro-Neuregulin-2 - Membrane-Bound Isoform antibody Anti-Pro-Nrg2 Cleaved Into - Neuregulin-2 antibody Anti-Nrg-2 antibody Anti-Divergent Of Neuregulin-1 antibody Anti-Don-1 antibody Anti-Neural- And Thymus-Derived Activator For Erbb Kinases antibody Anti-Ntak antibody Anti-NRG2 antibody Anti-NTAK antibody |
Information sourced from Uniprot.org