Anti-NRDC antibody (STJA0007682)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NRD1
General Information
| Short Description | Rabbit polyclonal anti-Nardilysin for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRDC |
| Gene ID | 4898 |
| Uniprot ID | NRDC_HUMAN |
| Immunogen | Synthesized peptide derived from human NRD1 |
| Specificity | This antibody detects endogenous levels of NRD1 at Human, Mouse, Rat |
Additional Info
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH). |
| Protein Name | NardilysinN-Arginine Dibasic ConvertaseNrd ConvertaseNrd-CNardilysin Convertase |
| Database Links | |
| Cellular Localisation | MitochondrionCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Nardilysin antibodyAnti-N-Arginine Dibasic Convertase antibodyAnti-Nrd Convertase antibodyAnti-Nrd-C antibodyAnti-Nardilysin Convertase antibodyAnti-NRDC antibodyAnti-NRD1 antibody |
Information sourced from Uniprot.org