| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRBF2 (10-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRBF2 |
| Gene ID: |
29982 |
| Uniprot ID: |
NRBF2_HUMAN |
| Immunogen Region: |
10-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 10-220 of human NRBF2 (NP_110386.2). |
| Immunogen Sequence: |
LAHQQSRRADRLLAAGKYEE AISCHKKAAAYLSEAMKLTQ SEQAHLSLELQRDSHMKQLL LIQERWKRAQREERLKAQQN TDKDAAAHLQTSHKPSAEDA EGQSPLSQKYSPSTEKCLPE IQGIFDRDPDTLLYLLQQKS EPAEPCIGSKAPKDDKTIIE EQATKIADLKRHVEFLVAEN ERLRKENKQLKAEKARLLKG PIEKELDVDAD |
| Tissue Specificity | Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma. |
| Function | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation. |
| Protein Name | Nuclear Receptor-Binding Factor 2Nrbf-2Comodulator Of Ppar And Rxr |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Nuclear Receptor-Binding Factor 2 antibodyAnti-Nrbf-2 antibodyAnti-Comodulator Of Ppar And Rxr antibodyAnti-NRBF2 antibodyAnti-COPR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
