• STJ73058 (1µg/ml) staining of HepG2 nuclear lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ73058 (0. 3µg/ml) staining of Pig Ovary lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-NR5A2/LRH1 antibody (Internal) (STJ73058)

SKU:
STJ73058-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-NR5A2/LRH1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: NR5A2
Gene ID: 2494
Uniprot ID: NR5A2_HUMAN
Immunogen Region: Internal
Accession Number: NP_995582.1; NP_003813.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_995582.1; NP_003813.1).
Immunogen Sequence: TDYDRSPFVTSPIS
Post Translational Modifications Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.
Function Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38.
Protein Name Nuclear Receptor Subfamily 5 Group A Member 2
Alpha-1-Fetoprotein Transcription Factor
B1-Binding Factor
Hb1f
Cyp7a Promoter-Binding Factor
Hepatocytic Transcription Factor
Liver Receptor Homolog 1
Lrh-1
Database Links Reactome: R-HSA-210747 O00482-1
Reactome: R-HSA-383280
Reactome: R-HSA-4090294 O00482-2
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Nuclear Receptor Subfamily 5 Group A Member 2 antibody
Anti-Alpha-1-Fetoprotein Transcription Factor antibody
Anti-B1-Binding Factor antibody
Anti-Hb1f antibody
Anti-Cyp7a Promoter-Binding Factor antibody
Anti-Hepatocytic Transcription Factor antibody
Anti-Liver Receptor Homolog 1 antibody
Anti-Lrh-1 antibody
Anti-NR5A2 antibody
Anti-B1F antibody
Anti-CPF antibody
Anti-FTF antibody

Information sourced from Uniprot.org

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