| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-NR5A2/LRH1 (328-338) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
NR5A2 |
| Gene ID: |
2494 |
| Uniprot ID: |
NR5A2_HUMAN |
| Immunogen Region: |
328-338 |
| Accession Number: |
NP_995582.1; NP_003813.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_995582.1; NP_003813.1). |
| Immunogen Sequence: |
QEQANRSKHEK |
| Post Translational Modifications | Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. |
| Function | Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. |
| Protein Name | Nuclear Receptor Subfamily 5 Group A Member 2Alpha-1-Fetoprotein Transcription FactorB1-Binding FactorHb1fCyp7a Promoter-Binding FactorHepatocytic Transcription FactorLiver Receptor Homolog 1Lrh-1 |
| Database Links | Reactome: R-HSA-210747 O00482-1Reactome: R-HSA-383280Reactome: R-HSA-4090294 O00482-2Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 5 Group A Member 2 antibodyAnti-Alpha-1-Fetoprotein Transcription Factor antibodyAnti-B1-Binding Factor antibodyAnti-Hb1f antibodyAnti-Cyp7a Promoter-Binding Factor antibodyAnti-Hepatocytic Transcription Factor antibodyAnti-Liver Receptor Homolog 1 antibodyAnti-Lrh-1 antibodyAnti-NR5A2 antibodyAnti-B1F antibodyAnti-CPF antibodyAnti-FTF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
