Anti-NR2F6 antibody [EM-51] (STJ16103379)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenRecombinant human NR2F6 protein expressed in E. coli
General Information
| Short Description | Mouse monoclonal anti-NR2F6 for use in FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EM-51 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | NR2F6 |
| Gene ID | 2063 |
| Uniprot ID | NR2F6_HUMAN |
| Immunogen | Recombinant human NR2F6 protein expressed in E. coli |
Additional Info
| Function | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock.is required early in the development of the locus coeruleus (LC). |
| Protein Name | Nuclear Receptor Subfamily 2 Group F Member 6V-Erba-Related Protein 2Ear-2 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group F Member 6 antibodyAnti-V-Erba-Related Protein 2 antibodyAnti-Ear-2 antibodyAnti-NR2F6 antibodyAnti-EAR2 antibodyAnti-ERBAL2 antibody |
Information sourced from Uniprot.org