Anti-NR2E3 antibody (STJ192043)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Photoreceptor-specific nuclear receptor for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NR2E3 |
| Gene ID | 10002 |
| Uniprot ID | NR2E3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | NR2E3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site. |
| Function | Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. |
| Protein Name | Photoreceptor-Specific Nuclear ReceptorNuclear Receptor Subfamily 2 Group E Member 3Retina-Specific Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Photoreceptor-Specific Nuclear Receptor antibodyAnti-Nuclear Receptor Subfamily 2 Group E Member 3 antibodyAnti-Retina-Specific Nuclear Receptor antibodyAnti-NR2E3 antibodyAnti-PNR antibodyAnti-RNR antibody |
Information sourced from Uniprot.org