Anti-NR2C2 antibody (410-490 aa) (STJ191123)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 410-490
General Information
| Short Description | Rabbit polyclonal anti-Nuclear receptor subfamily 2 group C member 2 (410-490 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NR2C2 |
| Gene ID | 7182 |
| Uniprot ID | NR2C2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 410-490 |
| Immunogen Region | 410-490 aa |
| Specificity | NR2C2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. |
| Protein Name | Nuclear Receptor Subfamily 2 Group C Member 2Orphan Nuclear Receptor Tak1Orphan Nuclear Receptor Tr4Testicular Receptor 4 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group C Member 2 antibodyAnti-Orphan Nuclear Receptor Tak1 antibodyAnti-Orphan Nuclear Receptor Tr4 antibodyAnti-Testicular Receptor 4 antibodyAnti-NR2C2 antibodyAnti-TAK1 antibodyAnti-TR4 antibody |
Information sourced from Uniprot.org