Anti-NPR3 antibody [R05-2R6] (STJA0036700)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Natriuretic Peptide Receptor C
General Information
| Short Description | Rabbit monoclonal anti-NPR3 for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-2R6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NPR3 |
| Gene ID | 4883 |
| Uniprot ID | ANPRC_HUMAN |
| Immunogen | A synthesized peptide derived from human Natriuretic Peptide Receptor C |
Additional Info
| Function | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. |
| Protein Name | Atrial Natriuretic Peptide Receptor 3Atrial Natriuretic Peptide Clearance ReceptorAtrial Natriuretic Peptide Receptor Type CAnp-CAnpr-CNpr-C |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide Receptor 3 antibodyAnti-Atrial Natriuretic Peptide Clearance Receptor antibodyAnti-Atrial Natriuretic Peptide Receptor Type C antibodyAnti-Anp-C antibodyAnti-Anpr-C antibodyAnti-Npr-C antibodyAnti-NPR3 antibodyAnti-ANPRC antibodyAnti-C5orf23 antibodyAnti-NPRC antibody |
Information sourced from Uniprot.org