Anti-NPR1 antibody (STJ191962)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Atrial natriuretic peptide receptor 1 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NPR1 |
| Gene ID | 4881 |
| Uniprot ID | ANPRA_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | ANPRA Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis. |
| Protein Name | Atrial Natriuretic Peptide Receptor 1Atrial Natriuretic Peptide Receptor Type AAnp-AAnpr-ANpr-AGuanylate Cyclase AGc-A |
| Database Links | Reactome: R-HSA-5578768 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide Receptor 1 antibodyAnti-Atrial Natriuretic Peptide Receptor Type A antibodyAnti-Anp-A antibodyAnti-Anpr-A antibodyAnti-Npr-A antibodyAnti-Guanylate Cyclase A antibodyAnti-Gc-A antibodyAnti-NPR1 antibodyAnti-ANPRA antibody |
Information sourced from Uniprot.org