Anti-NPPB antibody (100-150) {FITC} (STJ502175)

SKU:
STJ502175-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NPPB (100-150) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.8 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:200
ICC: 1:200
IF: 1:200
CFM: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NPPB
Gene ID: 4879
Uniprot ID: ANFB_HUMAN
Immunogen Region: 100-150
Specificity: No cross reactivity with proANP.
Immunogen: Synthetic peptide taken within amino acid region 100-150 on human proBNP.
Tissue Specificity Brain natriuretic peptide 32: Detected in the cardiac atria (at protein level). Detected in the kidney distal tubular cells (at protein level).
Post Translational Modifications The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP. This likely occurs after it has been secreted into the blood, either during circulation or in the target cells. CORIN also cleaves the precursor molecule at additional residues including Arg-99 and possibly Lys-105. In patients with heart failure, processing and degradation of natriuretic peptides B occurs but is delayed, possibly due to a decrease in enzyme level or activity of CORIN and DPP4. Brain natriuretic peptide 32: Undergoes further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides. Cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Degraded by IDE. During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro). O-glycosylated on at least seven residues. In cardiomyocytes, glycosylation at Thr-97 is essential for the stability and processing of the extracellular natriuretic peptides B. Glycosylation, especially at Thr-97, may also be important for brain natriuretic peptide 32 stability and/or extracellular distribution. Glycosylation at Thr-97 appears to inhibit FURIN- or CORIN-mediated proteolytic processing, at least in HEK293 cells.
Function Brain natriuretic peptide 32: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3. NT-proBNP: May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32. BNP(3-32): May have a role in cardio-renal homeostasis. Able to promote the production of cGMP.
Protein Name Natriuretic Peptides B
Brain Natriuretic Factor Prohormone
Preprobnp
Probnp
Gamma-Brain Natriuretic Peptide
Iso-Anp Cleaved Into - Nt-Probnp
Nt-Pro-Bnp
Nt-Probnp(1-76 - Probnp(3-108 - Brain Natriuretic Peptide 32
Bnp(1-32
Bnp-32
Brain Natriuretic Peptide
Bnp - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32
Des-Serpro-Bnp
Probnp(79-108 - Bnp(3-30 - Bnp(3-29 - Brain Natriuretic Peptide 29
Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29
Cellular Localisation Nt-Probnp: Secreted
Detected In Blood
Probnp(3-108): Secreted
Brain Natriuretic Peptide 32: Secreted
Bnp(3-32): Secreted
Alternative Antibody Names Anti-Natriuretic Peptides B antibody
Anti-Brain Natriuretic Factor Prohormone antibody
Anti-Preprobnp antibody
Anti-Probnp antibody
Anti-Gamma-Brain Natriuretic Peptide antibody
Anti-Iso-Anp Cleaved Into - Nt-Probnp antibody
Anti-Nt-Pro-Bnp antibody
Anti-Nt-Probnp(1-76 - Probnp(3-108 - Brain Natriuretic Peptide 32 antibody
Anti-Bnp(1-32 antibody
Anti-Bnp-32 antibody
Anti-Brain Natriuretic Peptide antibody
Anti-Bnp - Bnp(1-30 - Bnp(1-29 - Bnp(1-28 - Bnp(2-31 - Bnp(3-32 antibody
Anti-Des-Serpro-Bnp antibody
Anti-Probnp(79-108 - Bnp(3-30 - Bnp(3-29 - Brain Natriuretic Peptide 29 antibody
Anti-Bnp(4-32 - Bnp(4-31 - Bnp(4-30 - Bnp(4-29 - Bnp(4-27 - Bnp(5-32 - Bnp(5-31 - Bnp(5-29 antibody
Anti-NPPB antibody

Information sourced from Uniprot.org

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