Anti-NPHP3 antibody (1-130) (STJ111313)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NPHP3 (1-130) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NPHP3 |
| Gene ID | 27031 |
| Uniprot ID | NPHP3_HUMAN |
| Immunogen Region | 1-130 |
| Immunogen Sequence | MGTASSLVSPAGGEVIEDTY GAGGGEACEIPVEVKPKARL LRNSFRRGAGAAAGAGPGSL PRGVGAGGLLGASFKSTGSS VPELEYAAAEYERLRKEYEI FRVSKNQELLSMGRREAKLD TENKRLRAEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NPHP3 (NP_694972.3). |
Additional Info
| Tissue Specificity | Widely expressed at low level. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at very low level in brain and lung. |
| Function | Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. |
| Protein Name | Nephrocystin-3 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell ProjectionCiliumLocalization To Cilium Is Mediated Via Interaction With Unc119 And Unc119bWhich Bind To The Myristoyl Moiety Of The N-Terminus |
| Alternative Antibody Names | Anti-Nephrocystin-3 antibodyAnti-NPHP3 antibodyAnti-KIAA2000 antibody |
Information sourced from Uniprot.org