Anti-NOXO1 antibody (121-370) (STJ112503)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NOXO1 (121-370) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOXO1 |
| Gene ID | 124056 |
| Uniprot ID | NOXO1_HUMAN |
| Immunogen Region | 121-370 |
| Immunogen Sequence | QPLDLEPALPPGSRVILPTP EEQPLSRAAGRLSIHSLEAQ SLRCLQPFCTQDTRDRPFQA QAQESLDVLLRHPSGWWLVE NEDRQTAWFPAPYLEEAAPG QGREGGPSLGSSGPQFCASR AYESSRADELSVPAGARVRV LETSDRGWWLCRYGDRAGLL PAVLLRPEGLGALLSGTGFR GGDDPAGEARGFPEPSQATA PPPTVPTRPSPGAIQSRCCT VTRRALERRPRRQGRPRGC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 121-370 of human NOXO1 (NP_653204.1). |
Additional Info
| Tissue Specificity | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. |
| Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
| Protein Name | Nadph Oxidase Organizer 1Nadph Oxidase Regulatory ProteinNox Organizer 1Nox-Organizing Protein 1Sh3 And Px Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9673324 |
| Cellular Localisation | Isoform 3: Cell MembranePeripheral Membrane ProteinCytoplasmic SideIsoform 3 Associates With The Plasma Membrane In A Lipid-Dependent Manner |
| Alternative Antibody Names | Anti-Nadph Oxidase Organizer 1 antibodyAnti-Nadph Oxidase Regulatory Protein antibodyAnti-Nox Organizer 1 antibodyAnti-Nox-Organizing Protein 1 antibodyAnti-Sh3 And Px Domain-Containing Protein 5 antibodyAnti-NOXO1 antibodyAnti-P41NOX antibodyAnti-SH3PXD5 antibody |
Information sourced from Uniprot.org