| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NOXO1 (121-370) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NOXO1 |
| Gene ID: |
124056 |
| Uniprot ID: |
NOXO1_HUMAN |
| Immunogen Region: |
121-370 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 121-370 of human NOXO1 (NP_653204.1). |
| Immunogen Sequence: |
QPLDLEPALPPGSRVILPTP EEQPLSRAAGRLSIHSLEAQ SLRCLQPFCTQDTRDRPFQA QAQESLDVLLRHPSGWWLVE NEDRQTAWFPAPYLEEAAPG QGREGGPSLGSSGPQFCASR AYESSRADELSVPAGARVRV LETSDRGWWLCRYGDRAGLL PAVLLRPEGLGALLSGTGFR GGDDPAGEARGFPEPSQATA PPPTVPTRPSPGAIQSRCCT VTRRALERRPRRQGRPRGC |
| Tissue Specificity | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. |
| Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
| Protein Name | Nadph Oxidase Organizer 1Nadph Oxidase Regulatory ProteinNox Organizer 1Nox-Organizing Protein 1Sh3 And Px Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9673324 |
| Cellular Localisation | Isoform 3: Cell MembranePeripheral Membrane ProteinCytoplasmic SideIsoform 3 Associates With The Plasma Membrane In A Lipid-Dependent Manner |
| Alternative Antibody Names | Anti-Nadph Oxidase Organizer 1 antibodyAnti-Nadph Oxidase Regulatory Protein antibodyAnti-Nox Organizer 1 antibodyAnti-Nox-Organizing Protein 1 antibodyAnti-Sh3 And Px Domain-Containing Protein 5 antibodyAnti-NOXO1 antibodyAnti-P41NOX antibodyAnti-SH3PXD5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
