Anti-NOXA antibody [R01-5G3] (STJA0036355)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Noxa
General Information
| Short Description | Rabbit monoclonal anti-NOXA for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-5G3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PMAIP1 |
| Gene ID | 5366 |
| Uniprot ID | APR_HUMAN |
| Immunogen | A synthesized peptide derived from human Noxa |
Additional Info
| Tissue Specificity | Highly expressed in adult T-cell leukemia cell line. |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Pma-Induced Protein 1Immediate-Early-Response Protein AprProtein Noxa |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-111453Reactome: R-HSA-6803204 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Pma-Induced Protein 1 antibodyAnti-Immediate-Early-Response Protein Apr antibodyAnti-Protein Noxa antibodyAnti-PMAIP1 antibodyAnti-NOXA antibody |
Information sourced from Uniprot.org