Anti-Noxa antibody (aa: 1-16) (STJA0040876)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (MPGRKARRNA PVNPTR) as part of mouse Noxa (aa: 1-16) conjugated to diphtheria toxoid
General Information
| Short Description | Rabbit polyclonal anti-Noxa (aa: 1-16) for use in WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | WB 1:1000-1:2000 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
Target Information
| Gene Symbol | Pmaip1 |
| Gene ID | 58801 |
| Uniprot ID | APR_MOUSE |
| Immunogen | A synthetic peptide (MPGRKARRNA PVNPTR) as part of mouse Noxa (aa: 1-16) conjugated to diphtheria toxoid |
| Immunogen Region | aa: 1-16 |
| Immunogen Sequence | Mouse |
| Specificity | Western blot analysis of cells infected with Noxa adenoviruses and BAF indicates a high level of specificity for this antiserum. This antiserum cross-reacts with mouse. Not yet tested in other species. |
Additional Info
| Tissue Specificity | Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney. |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. |
| Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Protein Noxa |
| Database Links | Reactome: R-MMU-111448Reactome: -MMU-111453 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Protein Noxa antibodyAnti-Pmaip1 antibodyAnti-Noxa antibody |
Information sourced from Uniprot.org