Anti-NOP58 antibody (STJA0007599)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NOP58
General Information
| Short Description | Rabbit polyclonal anti-Nucleolar protein 58 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOP58 |
| Gene ID | 51602 |
| Uniprot ID | NOP58_HUMAN |
| Immunogen | Synthesized peptide derived from human NOP58 |
| Specificity | This antibody detects endogenous levels of NOP58 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Sumoylation is essential for high-affinity binding to snoRNAs. |
| Function | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). |
| Protein Name | Nucleolar Protein 58Nucleolar Protein 5 |
| Database Links | Reactome: R-HSA-4570464Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmLocalizes To The Nucleolus With A Minor Part Present In The Nucleoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 58 antibodyAnti-Nucleolar Protein 5 antibodyAnti-NOP58 antibodyAnti-NOL5 antibodyAnti-NOP5 antibodyAnti-HSPC120 antibody |
Information sourced from Uniprot.org