Anti-NOL12 antibody (1-213) (STJ116504)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NOL12 (1-213) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOL12 |
| Gene ID | 79159 |
| Uniprot ID | NOL12_HUMAN |
| Immunogen Region | 1-213 |
| Immunogen Sequence | MGRNKKKKRDGDDRRPRLVL SFDEEKRREYLTGFHKRKVE RKKAAIEEIKQRLKEEQRKL REERHQEYLKMLAEREEALE EADELDRLVTAKTESVQYDH PNHTVTVTTISDLDLSGARL LGLTPPEGGAGDRSEEEASS TEKPTKALPRKSRDPLLSQR ISSLTASLHAHSRKKVKRKH PRRAQDSKKPPRAPRTSKAQ RRRLTGKARHSGE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human NOL12 (NP_077289.1). |
Additional Info
| Function | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. |
| Protein Name | Nucleolar Protein 12 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusCytoplasm |
| Alternative Antibody Names | Anti-Nucleolar Protein 12 antibodyAnti-NOL12 antibody |
Information sourced from Uniprot.org