Anti-NOC2L antibody (602-651) (STJ94525)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NOC2L. AA range:602-651
General Information
| Short Description | Rabbit polyclonal anti-Nucleolar complex protein 2 homolog (602-651) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOC2L |
| Gene ID | 26155 |
| Uniprot ID | NOC2L_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NOC2L. AA range:602-651 |
| Immunogen Region | 602-651 |
| Specificity | NOC2L Polyclonal Antibody detects endogenous levels of NOC2L protein. |
Additional Info
| Function | Acts as an inhibitor of histone acetyltransferase activity.prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. |
| Protein Name | Nucleolar Complex Protein 2 HomologProtein Noc2 HomologNoc2-Like ProteinNovel Inhat Repressor |
| Database Links | Reactome: R-HSA-6804756 |
| Cellular Localisation | NucleusNucleoplasmNucleolusTranslocates From The Nucleoli To The Nucleoplasm In Presence Of Several Stressors Like Ultraviolet Irradiation And Actinomycin-DPredominantly Detected In The Nucleoli In Non-Mitotic CellsPredominantly Detected In Nucleoplasma In Cells Undergoing Mitosis |
| Alternative Antibody Names | Anti-Nucleolar Complex Protein 2 Homolog antibodyAnti-Protein Noc2 Homolog antibodyAnti-Noc2-Like Protein antibodyAnti-Novel Inhat Repressor antibodyAnti-NOC2L antibodyAnti-NIR antibody |
Information sourced from Uniprot.org