| Function | Acts as an inhibitor of histone acetyltransferase activity.prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. |
| Protein Name | Nucleolar Complex Protein 2 HomologProtein Noc2 HomologNoc2-Like ProteinNovel Inhat Repressor |
| Database Links | Reactome: R-HSA-6804756 |
| Cellular Localisation | NucleusNucleoplasmNucleolusTranslocates From The Nucleoli To The Nucleoplasm In Presence Of Several Stressors Like Ultraviolet Irradiation And Actinomycin-DPredominantly Detected In The Nucleoli In Non-Mitotic CellsPredominantly Detected In Nucleoplasma In Cells Undergoing Mitosis |
| Alternative Antibody Names | Anti-Nucleolar Complex Protein 2 Homolog antibodyAnti-Protein Noc2 Homolog antibodyAnti-Noc2-Like Protein antibodyAnti-Novel Inhat Repressor antibodyAnti-NOC2L antibodyAnti-NIR antibody |
Information sourced from Uniprot.org
