| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMU (35-174) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NMU |
| Gene ID: |
10874 |
| Uniprot ID: |
NMU_HUMAN |
| Immunogen Region: |
35-174 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 35-174 of human NMU (NP_006672.1). |
| Immunogen Sequence: |
ACRGAPILPQGLQPEQQLQL WNEIDDTCSSFLSIDSQPQA SNALEELCFMIMGMLPKPQE QDEKDNTKRFLFHYSKTQKL GKSNVVSSVVHPLLQLVPHL HERRMKRFRVDEEFQSPFAS QSRGYFLFRPRNGRRSAGFI |
| Tissue Specificity | Expressed throughout the enteric nervous system with highest levels being found in the jejunum. |
| Function | Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. |
| Protein Name | Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36Nurp36 - Neuromedin Precursor-Related Peptide 33Nurp33 - Neuromedin-U-25Nmu-25 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neuromedin-U Cleaved Into - Neuromedin Precursor-Related Peptide 36 antibodyAnti-Nurp36 - Neuromedin Precursor-Related Peptide 33 antibodyAnti-Nurp33 - Neuromedin-U-25 antibodyAnti-Nmu-25 antibodyAnti-NMU antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
