Anti-NMNAT3 antibody (149-162) (STJ72623)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NMNAT3 (149-162) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IF/FC |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary testing showed a band at approx. 26kDa in Caco-2, A431 and A549 cell lysate at a concentration of 2ug/ml (calculated Mwt. of 24.1kDa according to NP_835471.1). Primary incu |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NMNAT3 |
| Gene ID | 349565 |
| Uniprot ID | NMNA3_HUMAN |
| Accession Number | NP_835471.1; NP_001186976.1 |
| Immunogen Region | 149-162 |
| Immunogen Sequence | QHNIHLAKEPVQNE |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1). |
Additional Info
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3Nmn/Namn Adenylyltransferase 3Nicotinamide-Nucleotide Adenylyltransferase 3Nmn Adenylyltransferase 3Nicotinate-Nucleotide Adenylyltransferase 3Namn Adenylyltransferase 3Pyridine Nucleotide Adenylyltransferase 3Pnat-3 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3 antibodyAnti-Nmn/Namn Adenylyltransferase 3 antibodyAnti-Nicotinamide-Nucleotide Adenylyltransferase 3 antibodyAnti-Nmn Adenylyltransferase 3 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 3 antibodyAnti-Namn Adenylyltransferase 3 antibodyAnti-Pyridine Nucleotide Adenylyltransferase 3 antibodyAnti-Pnat-3 antibodyAnti-NMNAT3 antibodyAnti-FKSG76 antibody |
Information sourced from Uniprot.org