Anti-NMNAT3 antibody (1-215) (STJ116675)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NMNAT3 (1-215) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NMNAT3 |
| Gene ID | 349565 |
| Uniprot ID | NMNA3_HUMAN |
| Immunogen Region | 1-215 |
| Immunogen Sequence | MYQVIQGIISPVNDTYGKKD LAASHHRVAMARLALQTSDW IRVDPWESEQAQWMETVKVL RHHHSKLLRSPPQMEGPDHG KALFSTPAAVPELKLLCGAD VLKTFQTPNLWKDAHIQEIV EKFGLVCVGRVGHDPKGYIA ESPILRMHQHNIHLAKEPVQ NEISATYIRRALGQGQSVKY LIPDAVITYIKDHGLYTKGS TWKGKSTQSTEGKTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NMNAT3 (NP_835471.1). |
Additional Info
| Tissue Specificity | Expressed in lung and spleen with lower levels in placenta and kidney. |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins.this function may be independent of its NAD(+) synthesis activity. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3Nmn/Namn Adenylyltransferase 3Nicotinamide-Nucleotide Adenylyltransferase 3Nmn Adenylyltransferase 3Nicotinate-Nucleotide Adenylyltransferase 3Namn Adenylyltransferase 3Pyridine Nucleotide Adenylyltransferase 3Pnat-3 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3 antibodyAnti-Nmn/Namn Adenylyltransferase 3 antibodyAnti-Nicotinamide-Nucleotide Adenylyltransferase 3 antibodyAnti-Nmn Adenylyltransferase 3 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 3 antibodyAnti-Namn Adenylyltransferase 3 antibodyAnti-Pyridine Nucleotide Adenylyltransferase 3 antibodyAnti-Pnat-3 antibodyAnti-NMNAT3 antibodyAnti-FKSG76 antibody |
Information sourced from Uniprot.org