| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMNAT3 (1-215) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NMNAT3 |
| Gene ID: |
349565 |
| Uniprot ID: |
NMNA3_HUMAN |
| Immunogen Region: |
1-215 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NMNAT3 (NP_835471.1). |
| Immunogen Sequence: |
MYQVIQGIISPVNDTYGKKD LAASHHRVAMARLALQTSDW IRVDPWESEQAQWMETVKVL RHHHSKLLRSPPQMEGPDHG KALFSTPAAVPELKLLCGAD VLKTFQTPNLWKDAHIQEIV EKFGLVCVGRVGHDPKGYIA ESPILRMHQHNIHLAKEPVQ NEISATYIRRALGQGQSVKY LIPDAVITYIKDHGLYTKGS TWKGKSTQSTEGKTS |
| Tissue Specificity | Expressed in lung and spleen with lower levels in placenta and kidney. |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3Nmn/Namn Adenylyltransferase 3Nicotinamide-Nucleotide Adenylyltransferase 3Nmn Adenylyltransferase 3Nicotinate-Nucleotide Adenylyltransferase 3Namn Adenylyltransferase 3Pyridine Nucleotide Adenylyltransferase 3Pnat-3 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 3 antibodyAnti-Nmn/Namn Adenylyltransferase 3 antibodyAnti-Nicotinamide-Nucleotide Adenylyltransferase 3 antibodyAnti-Nmn Adenylyltransferase 3 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 3 antibodyAnti-Namn Adenylyltransferase 3 antibodyAnti-Pyridine Nucleotide Adenylyltransferase 3 antibodyAnti-Pnat-3 antibodyAnti-NMNAT3 antibodyAnti-FKSG76 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
