Anti-NMNAT2 antibody (218-268) (STJA0006540)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NMNA2 AA range: 218-268
General Information
| Short Description | Rabbit polyclonal anti-Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (218-268) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NMNAT2 |
| Gene ID | 23057 |
| Uniprot ID | NMNA2_HUMAN |
| Immunogen | Synthesized peptide derived from human NMNA2 AA range: 218-268 |
| Immunogen Region | 218-268 |
| Specificity | This antibody detects endogenous levels of human NMNA2 |
Additional Info
| Post Translational Modifications | Degraded in response to injured neurite. Degradation is caused by polyubiquitination by MYCBP2 after recognition by FBXO45. Palmitoylated.palmitoylation is required for membrane association. |
| Function | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16. May be involved in the maintenance of axonal integrity. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2Nmn/Namn Adenylyltransferase 2Nicotinamide Mononucleotide Adenylyltransferase 2Nmn Adenylyltransferase 2Nicotinate-Nucleotide Adenylyltransferase 2Namn Adenylyltransferase 2 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic Vesicle MembraneCytoplasmCell ProjectionAxonDelivered To Axons With Golgi-Derived Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn/Namn Adenylyltransferase 2 antibodyAnti-Nicotinamide Mononucleotide Adenylyltransferase 2 antibodyAnti-Nmn Adenylyltransferase 2 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 2 antibodyAnti-Namn Adenylyltransferase 2 antibodyAnti-NMNAT2 antibodyAnti-C1orf15 antibodyAnti-KIAA0479 antibody |
Information sourced from Uniprot.org