| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMNAT1 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NMNAT1 |
| Gene ID: |
64802 |
| Uniprot ID: |
NMNA1_HUMAN |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human NMNAT1 (NP_073624.2). |
| Immunogen Sequence: |
MENSEKTEVVLLACGSFNPI TNMHLRLFELAKDYMNGTGR YTVVKGIISPVGDAYKKKGL IPAYHRVIMAELATKNSKWV EVDTWESLQKEWKETLKVLR HHQEKLEASDCDHQQNSPTL ERPGRKRKWTETQDSSQKKS LEPKTKAVPK |
| Tissue Specificity | Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form.nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults. |
| Protein Name | Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1Nmn/Namn Adenylyltransferase 1Nicotinamide-Nucleotide Adenylyltransferase 1Nmn Adenylyltransferase 1Nicotinate-Nucleotide Adenylyltransferase 1Namn Adenylyltransferase 1 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 1 antibodyAnti-Nmn/Namn Adenylyltransferase 1 antibodyAnti-Nicotinamide-Nucleotide Adenylyltransferase 1 antibodyAnti-Nmn Adenylyltransferase 1 antibodyAnti-Nicotinate-Nucleotide Adenylyltransferase 1 antibodyAnti-Namn Adenylyltransferase 1 antibodyAnti-NMNAT1 antibodyAnti-NMNAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
