Anti-NME8 antibody (299-588) (STJ11102862)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NME8 (299-588) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NME8 |
| Gene ID | 51314 |
| Uniprot ID | TXND3_HUMAN |
| Immunogen Region | 299-588 |
| Immunogen Sequence | FMDAFFPDFKKMKSMKLEKT LALLRPNLFHERKDDVLRII KDEDFKILEQRQVVLSEKEA QALCKEYENEDYFNKLIENM TSGPSLALVLLRDNGLQYWK QLLGPRTVEEAIEYFPESLC AQFAMDSLPVNQLYGSDSLE TAEREIQHFFPLQSTLGLIK PHATSEQREQILKIVKEAGF DLTQVKKMFLTPEQIEKIYP KVTGKDFYKDLLEMLSVGPS MVMILTKWNAVAEWRRLMG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 299-588 of human NME8 (NP_057700.3). |
Additional Info
| Tissue Specificity | Testis-specific. Expressed only in primary spermatocytes and round spermatids. |
| Function | Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds. Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair. |
| Protein Name | Thioredoxin Domain-Containing Protein 33'-5' Exonuclease Nme8Nm23-H8Nme/Nm23 Family Member 8Spermatid-Specific Thioredoxin-2Sptrx-2 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thioredoxin Domain-Containing Protein 3 antibodyAnti-3'-5' Exonuclease Nme8 antibodyAnti-Nm23-H8 antibodyAnti-Nme/Nm23 Family Member 8 antibodyAnti-Spermatid-Specific Thioredoxin-2 antibodyAnti-Sptrx-2 antibodyAnti-NME8 antibodyAnti-SPTRX2 antibodyAnti-TXNDC3 antibody |
Information sourced from Uniprot.org