Anti-NMBR antibody (STJ13100204)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse NMBR conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human and marmoset.
General Information
| Short Description | Rabbit polyclonal anti-NMBR for use in IHC in Rat, Mouse, Human and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Rabbit |
| Reactivity | Rat/Mouse/Human/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC. A dilution of 1:500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | NMBR |
| Gene ID | 4829 |
| Uniprot ID | NMBR_HUMAN |
| Immunogen | A synthetic peptide from mouse NMBR conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human and marmoset. |
| Specificity | Specific for NMBR. |
Additional Info
| Function | Receptor for neuromedin-B. Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem. These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response. Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide. Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6. Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R. |
| Protein Name | Neuromedin-B ReceptorNmb-REpididymis Tissue Protein Li 185aNeuromedin-B-Preferring Bombesin Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Neuromedin-B Receptor antibodyAnti-Nmb-R antibodyAnti-Epididymis Tissue Protein Li 185a antibodyAnti-Neuromedin-B-Preferring Bombesin Receptor antibodyAnti-NMBR antibody |
Information sourced from Uniprot.org