Anti-NLRP9 antibody (STJA0004543)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human NLRP9
General Information
| Short Description | Rabbit polyclonal anti-Nacht-Lrr And Pyd Domains-Containing Protein 9 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:50-1:200 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | NLRP9 |
| Gene ID | 338321 |
| Uniprot ID | NLRP9_HUMAN |
| Immunogen | Synthetic peptide of human NLRP9 |
Additional Info
| Tissue Specificity | Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells. Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes. |
| Function | As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 9Nucleotide-Binding Oligomerization Domain Protein 6Pyrin And Nacht-Containing Protein 12 |
| Database Links | |
| Cellular Localisation | CytoplasmInflammasome |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 9 antibodyAnti-Nucleotide-Binding Oligomerization Domain Protein 6 antibodyAnti-Pyrin And Nacht-Containing Protein 12 antibodyAnti-NLRP9 antibodyAnti-NALP9 antibodyAnti-NOD6 antibodyAnti-PAN12 antibody |
Information sourced from Uniprot.org