Anti-NLRP5 antibody (C-Term) (STJ73214)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-NLRP5 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 130kDa band observed in Human Ovary lysates (calculated MW of 134kDa according to NP_703148.4). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | NLRP5 |
| Gene ID | 126206 |
| Uniprot ID | NALP5_HUMAN |
| Accession Number | NP_703148.4 |
| Immunogen Region | C-Term |
| Immunogen Sequence | DGSWHSFDEDDR |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKCE. |
| Function | As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 5Mater Protein HomologMaternal Antigen That Embryos Require |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleCortical GranuleMitochondrionNucleusNucleolusCytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 5 antibodyAnti-Mater Protein Homolog antibodyAnti-Maternal Antigen That Embryos Require antibodyAnti-NLRP5 antibodyAnti-MATER antibodyAnti-NALP5 antibody |
Information sourced from Uniprot.org