| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NLRP5 (157-256) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NLRP5 |
| Gene ID: |
126206 |
| Uniprot ID: |
NALP5_HUMAN |
| Immunogen Region: |
157-256 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 157-256 of human NLRP5 (NP_703148.4). |
| Immunogen Sequence: |
TMTDQGPSKEKVPGISQAVQ QDSATAAETKEQEISQAMEQ EGATAAETEEQEISQAMEQE GATAAETEEQGHGGDTWDYK SHVMTKFAEEEDVRRSFENT |
| Tissue Specificity | Expressed in cumulus cells (at protein level). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord. |
| Post Translational Modifications | Phosphorylated by PRKCE. |
| Function | As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 5Mater Protein HomologMaternal Antigen That Embryos Require |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleCortical GranuleMitochondrionNucleusNucleolusCytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 5 antibodyAnti-Mater Protein Homolog antibodyAnti-Maternal Antigen That Embryos Require antibodyAnti-NLRP5 antibodyAnti-MATER antibodyAnti-NALP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
