| Tissue Specificity | Expressed in cumulus cells (at protein level). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord. |
| Post Translational Modifications | Phosphorylated by PRKCE. |
| Function | Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 5Mater Protein HomologMaternal Antigen That Embryos Require |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic VesicleSecretory VesicleCortical GranuleMitochondrionNucleusNucleolusGolgi ApparatusCore Component Of Cytoplasmic Lattices In OocytesIn The Subcortical Cytoplasm Of Early Embryos From The 1-Cell To The Blastocyst StagesFrom The 2-Cell StageStill Detected In The SubcortexBut Excluded From Cell-Cell Contact RegionsExpression Largely Disappears In BlastocystsLocated In Mitochondria And Nucleoli In Primary Follicle Oocytes |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 5 antibodyAnti-Mater Protein Homolog antibodyAnti-Maternal Antigen That Embryos Require antibodyAnti-NLRP5 antibodyAnti-MATER antibodyAnti-NALP5 antibody |
Information sourced from Uniprot.org
